Incubator Accessories
Diagnostic Biosystems CYCLIN D1 Cyclin D1 (EP12)
Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition. Amplification or overexpression of Cyclin D1 plays a pivotal role in the development of various human cancers including breast cancer, colon cancer, melanoma, prostate cancer and lymphoma. It is useful to differentiate mantle cell lymphoma from small cleaved cell lymphoma. Rabbit monoclonal antibodies to Cyclin D1 showed the highest sensitivity to detect this antigen in formalin fixed paraffin embedded tissue as compared to several other clones.
Diagnostic Biosystems CDX2 CDX2 (EP25)
The caudal-related homeodomain protein 2, CDX-2, is a transcription factor which is expressed in the intestine and is thought to play an important role in the proliferation and differentiation of intestinal epithelial cells. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas, intestinal metaplasia of the stomach and intestinal type gastric cancer. In human colorectal cancer, the expression of both CDX2 and carbonic anhydrase 1, a gene regulated by CDX2, is reduced or absent. CDX-2 is one of the important regulators in defining pathways for coordinate control of drug metabolism in the gastrointestinal tract.
Diagnostic Biosystems UNOVUE MOUSE HRP DETECTION RE UnoVue™ Mouse HRP Detection Reagent
UnoVue Mouse HRP Detection Reagent is suitable for use with mouse all Ig antibodies, both monoclonal and polyclonal. The reagents can be used for manual staining or with automated staining instruments and are well suited for multiplex immunohistochemical staining assays.
Diagnostic Biosystems MYOGENIN Myogenin
This antibody is specific to 34 kDa protein known as myogenin. Myogenin is a member of family of myogenic regulatory genes which includes MyoD, myf5 and MRF4. These genes encode a set of transcription factors which are essential for muscle development. Expression of myogenin is restricted to cells of skeletal muscle origin.
Diagnostic Biosystems PAPANICOLAOU RED STAIN KIT Papanicolaou Red Stain Kit
The Papanicolaou (PAP) Stain Kit is designed to differentiate between a variety of cells in vaginal smears for detection of vaginal, uterine and cervical cancer.
Diagnostic Biosystems VON KOSSA Von Kossa
The Calcium Stain Kit (Modified Von Kossa) is intended for use in the histological visualization of calcium deposits in paraffin sections.
Diagnostic Biosystems PMS2 PMS2
Postmeiotic segregation increased 2 or PMS2 was originally discovered in S. cerevisiae and is part of the mismatch repair system. It resides on 7p22.2 and its gene product partners with MLH1 to help detect mismatches in DNA. Mutations in PMS2 have been reported in about two percent of families with Lynch syndrome (hereditary nonpolyposis colorectal cancer).
Diagnostic Biosystems HPV16 HPV 16
This antibody stains with HPV type 16. L1 protein is a major capsid protein of HPV type 16. HPV 6 and 11 have been associated with relatively benign diseases such as genital warts but type 16 and 18 are strongly associated with cervical, vaginal and vulvar malignancies.
Diagnostic Biosystems CYCLIN D1 Cyclin D1 (SP4)
Cyclin D1 or PRAD-1 or bcl-1 is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein. It is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL).
Diagnostic Biosystems MOUSE AND RABBIT LINK Desmin (D33)
Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.
Diagnostic Biosystems LUXOL FAST BLUE Luxol Fast Blue
The Luxol Fast Blue Stain Kit is designed for staining myelin/myelinated axons and Nissil substance on formalin fixed, paraffin-embedded tissue. This product is used for identifying the basic neuronal structure in brain or spinal cord sections.
Diagnostic Biosystems MAST CELL TRYPTASE Mast Cell Tryptase
This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Mast cells contain a number of preformed chemicals mediators such as histamine, chymase, carboxypeptidase, and proteolytic tryptase. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation.
Diagnostic Biosystems HELICOBACTER PYLORI Helicobacter Pylori
This antibody reacts with the 54 kDa (flagellin) of H. pylori. The antibody stains the bacteria present on the surface of the epithelium or in the cytoplasm of the epithelial cells. H. pylori is known to cause peptic ulcer and chronic gastritis in humans.
Diagnostic Biosystems PTEN PTEN (Tumor Suppressor)
PTEN gene is a tumor suppressor gene that maps to chromosome 10q23. PTEN, a novel tumor suppressor, functions as a regulator of both cell cycle progression and apoptosis ). Potentially, mutation and deletion of PTEN gene may result in a new signal transduction pathway related to human malignant tumors. Studies have demonstrated a reduction of PTEN expression in advanced breast cancers
Diagnostic Biosystems KI-67 ANTIGEN Ki-67 Antigen
Ki-67 is a nuclear protein, which is expressed in proliferating cells. Ki-67 is preferentially expressed during late G1-, S-, M-, and G2-phases of the cell cycle, while cells in the G0 (quiescent) phase are negative for this protein.